Tay-Sachs Disease

Tay-Sachs disease is a genetic disease that causes progressive deterioration of nerve cells, mental and physical abilities. It is an autosomal recessive genetic disease which means that an affected child would need to have inherited a mutated gene from both parents. The mutation is in the α-subunit locus on chromosome 15 which results in a deficiency of the enzyme hexosaminidase A. This enzyme is required to catabolize GM2 gangliosides. If a substance is not properly broken down, Continue reading